27 research outputs found
Accounting for the tongue-and-groove effect using a robust direct aperture optimization approach
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98733/1/MPH001266.pd
4,4′-Bipyridine–2,3,4,5,6-pentafluorobenzoic acid (1/2)
In the title 1:2 adduct, C10H8N2·2C7HF5O2, the complete 4,4′-bipyridine molecule is generated by a crystallographic twofold axis. The components of the adduct are linked by intermolecular O—H⋯N hydrogen bonds and further connected by a combination of C—H⋯O, C—H⋯F and F⋯F [2.859 (2) Å] interactions
1,10-Phenanthrolinium 2,3,4,5,6-pentafluorobenzoate–2,3,4,5,6-pentafluorobenzoic acid (1/2)
In the title compound, C12H9N2
+·C7F5O2
−·2C7HF5O2, the cation and anion are linked by an N—H⋯O hydrogen bond. The neutral molecules bond to the anion via O—H⋯O hydrogen bonds to form associations of one cation, one anion and two neutral molecules. Intermolecular C—H⋯O, C—H⋯F, F⋯F [shortest contact = 2.768 (8) Å], F⋯π [shortest contact = 3.148 (13) Å] and π–π [shortest centroid–centroid separation = 3.689 (5) Å] interactions further link the components to form a three-dimensional network
Ultrafast treatment plan optimization for volumetric modulated arc therapy (VMAT)
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134981/1/mp1675.pd
Beam Orientation Optimization for Intensity Modulated Radiation Therapy using Adaptive l1 Minimization
Beam orientation optimization (BOO) is a key component in the process of IMRT
treatment planning. It determines to what degree one can achieve a good
treatment plan quality in the subsequent plan optimization process. In this
paper, we have developed a BOO algorithm via adaptive l_1 minimization.
Specifically, we introduce a sparsity energy function term into our model which
contains weighting factors for each beam angle adaptively adjusted during the
optimization process. Such an energy term favors small number of beam angles.
By optimizing a total energy function containing a dosimetric term and the
sparsity term, we are able to identify the unimportant beam angles and
gradually remove them without largely sacrificing the dosimetric objective. In
one typical prostate case, the convergence property of our algorithm, as well
as the how the beam angles are selected during the optimization process, is
demonstrated. Fluence map optimization (FMO) is then performed based on the
optimized beam angles. The resulted plan quality is presented and found to be
better than that obtained from unoptimized (equiangular) beam orientations. We
have further systematically validated our algorithm in the contexts of 5-9
coplanar beams for 5 prostate cases and 1 head and neck case. For each case,
the final FMO objective function value is used to compare the optimized beam
orientations and the equiangular ones. It is found that, our BOO algorithm can
lead to beam configurations which attain lower FMO objective function values
than corresponding equiangular cases, indicating the effectiveness of our BOO
algorithm.Comment: 19 pages, 2 tables, and 5 figure
GPU-based ultra-fast direct aperture optimization for online adaptive radiation therapy
Online adaptive radiation therapy (ART) has great promise to significantly
reduce normal tissue toxicity and/or improve tumor control through real-time
treatment adaptations based on the current patient anatomy. However, the major
technical obstacle for clinical realization of online ART, namely the inability
to achieve real-time efficiency in treatment re-planning, has yet to be solved.
To overcome this challenge, this paper presents our work on the implementation
of an intensity modulated radiation therapy (IMRT) direct aperture optimization
(DAO) algorithm on graphics processing unit (GPU) based on our previous work on
CPU. We formulate the DAO problem as a large-scale convex programming problem,
and use an exact method called column generation approach to deal with its
extremely large dimensionality on GPU. Five 9-field prostate and five 5-field
head-and-neck IMRT clinical cases with 5\times5 mm2 beamlet size and
2.5\times2.5\times2.5 mm3 voxel size were used to evaluate our algorithm on
GPU. It takes only 0.7~2.5 seconds for our implementation to generate optimal
treatment plans using 50 MLC apertures on an NVIDIA Tesla C1060 GPU card. Our
work has therefore solved a major problem in developing ultra-fast
(re-)planning technologies for online ART
GPU-based Fast Low-dose Cone Beam CT Reconstruction via Total Variation
Cone-beam CT (CBCT) has been widely used in image guided radiation therapy
(IGRT) to acquire updated volumetric anatomical information before treatment
fractions for accurate patient alignment purpose. However, the excessive x-ray
imaging dose from serial CBCT scans raises a clinical concern in most IGRT
procedures. The excessive imaging dose can be effectively reduced by reducing
the number of x-ray projections and/or lowering mAs levels in a CBCT scan. The
goal of this work is to develop a fast GPU-based algorithm to reconstruct high
quality CBCT images from undersampled and noisy projection data so as to lower
the imaging dose. The CBCT is reconstructed by minimizing an energy functional
consisting of a data fidelity term and a total variation regularization term.
We developed a GPU-friendly version of the forward-backward splitting algorithm
to solve this model. A multi-grid technique is also employed. We test our CBCT
reconstruction algorithm on a digital NCAT phantom and a head-and-neck patient
case. The performance under low mAs is also validated using a physical Catphan
phantom and a head-and-neck Rando phantom. It is found that 40 x-ray
projections are sufficient to reconstruct CBCT images with satisfactory quality
for IGRT patient alignment purpose. Phantom experiments indicated that CBCT
images can be successfully reconstructed with our algorithm under as low as 0.1
mAs/projection level. Comparing with currently widely used full-fan
head-and-neck scanning protocol of about 360 projections with 0.4
mAs/projection, it is estimated that an overall 36 times dose reduction has
been achieved with our algorithm. Moreover, the reconstruction time is about
130 sec on an NVIDIA Tesla C1060 GPU card, which is estimated ~100 times faster
than similar iterative reconstruction approaches.Comment: 20 pages, 10 figures, Paper was revised and more testing cases were
added
Real-time volumetric image reconstruction and 3D tumor localization based on a single x-ray projection image for lung cancer radiotherapy
Purpose: To develop an algorithm for real-time volumetric image
reconstruction and 3D tumor localization based on a single x-ray projection
image for lung cancer radiotherapy. Methods: Given a set of volumetric images
of a patient at N breathing phases as the training data, we perform deformable
image registration between a reference phase and the other N-1 phases,
resulting in N-1 deformation vector fields (DVFs). These DVFs can be
represented efficiently by a few eigenvectors and coefficients obtained from
principal component analysis (PCA). By varying the PCA coefficients, we can
generate new DVFs, which, when applied on the reference image, lead to new
volumetric images. We then can reconstruct a volumetric image from a single
projection image by optimizing the PCA coefficients such that its computed
projection matches the measured one. The 3D location of the tumor can be
derived by applying the inverted DVF on its position in the reference image.
Our algorithm was implemented on graphics processing units (GPUs) to achieve
real-time efficiency. We generated the training data using a realistic and
dynamic mathematical phantom with 10 breathing phases. The testing data were
360 cone beam projections corresponding to one gantry rotation, simulated using
the same phantom with a 50% increase in breathing amplitude. Results: The
average relative image intensity error of the reconstructed volumetric images
is 6.9% +/- 2.4%. The average 3D tumor localization error is 0.8 mm +/- 0.5 mm.
On an NVIDIA Tesla C1060 GPU card, the average computation time for
reconstructing a volumetric image from each projection is 0.24 seconds (range:
0.17 and 0.35 seconds). Conclusions: We have shown the feasibility of
reconstructing volumetric images and localizing tumor positions in 3D in near
real-time from a single x-ray image.Comment: 8 pages, 3 figures, submitted to Medical Physics Lette
3D tumor localization through real-time volumetric x-ray imaging for lung cancer radiotherapy
Recently we have developed an algorithm for reconstructing volumetric images
and extracting 3D tumor motion information from a single x-ray projection. We
have demonstrated its feasibility using a digital respiratory phantom with
regular breathing patterns. In this work, we present a detailed description and
a comprehensive evaluation of the improved algorithm. The algorithm was
improved by incorporating respiratory motion prediction. The accuracy and
efficiency were then evaluated on 1) a digital respiratory phantom, 2) a
physical respiratory phantom, and 3) five lung cancer patients. These
evaluation cases include both regular and irregular breathing patterns that are
different from the training dataset. For the digital respiratory phantom with
regular and irregular breathing, the average 3D tumor localization error is
less than 1 mm. On an NVIDIA Tesla C1060 GPU card, the average computation time
for 3D tumor localization from each projection ranges between 0.19 and 0.26
seconds, for both regular and irregular breathing, which is about a 10%
improvement over previously reported results. For the physical respiratory
phantom, an average tumor localization error below 1 mm was achieved with an
average computation time of 0.13 and 0.16 seconds on the same GPU card, for
regular and irregular breathing, respectively. For the five lung cancer
patients, the average tumor localization error is below 2 mm in both the axial
and tangential directions. The average computation time on the same GPU card
ranges between 0.26 and 0.34 seconds